Measurement of Protein C and protein S Level among Sudanese Hypertensive Patients

Abstract

Background

Hypertension is a prevalent situation in which the long term    force of  the blood against artery walls is high enough that it may be  eventually cause health problems, like  heart disease.

Materials and Methods

This was Analytical case control study conducted at wad madani teaching hospital, Gazera , Sudan during the period from April  2022 to August 2022, to assess  Protein C and protein S level among Sudanese hypertensive patients. 30 patients were selected as a case group, and apparently healthy donors with no history of any coagulation problems or any chronic disease were selected as control group. 2.8 ml of venous blood samples were collected in Tri Sodium Citrate anticoagulant.  Protein C and protein S level was measured by (BIOBASE_EL_10 Microplate reader).

Results: The mean of protein C  in case was(101.3±33.5)  and decreased in 23.3% of cases,    protein S mean was (94.2±29.5) and decreased  in only 10% of cases , while in the control group the mean of protein C  was(125.8±20.2)  and  protein S mean was (116.3±18.3).   when compared protein C and S  means between case and control groups there was a  highly significant decreased with ( p value 0.00) , in the other hand when compared protein C and S  means with the age ,gender, and other chronic diseases in the case group  there was in significant differences , Also the result showed appositive correlation between protein C and S .   

Conclusion:

In case group there was significant decrease of protein C and S when compared to control group, insignificant difference of protein C and S level with Socio- demographic data