Cerebro-Spinal Fluid Findings in Neuro-Covid

Abstract

withinterest we read the review article by Lewis et al. about the cerebro-spinal fluid (CSF) findings in patients  infected  with  SARS-CoV-2  who  manifestedclinically  with  neuro-COVID  [1].  It  was  found  that the  CSF  was  positive  for  SARS-CoV-2  RNA  in  only  6%  of the  patients  with  neuro-COVID  and  that  only 12%  had  developed  intrathecal  anti-SARS-CoV-2  antibodies  [1].  It  was  concluded  that  though  neuro-invasion of  SARS-CoV-2  and  intrathecal  antibody  synthesis  are  rare  [1],  CSF  biomarkers  may  have diagnostic,  therapeutic,  and  prognostic  benefit  [1].  The  review  is  appealing  but  raises  the  followin1g comments and concerns