There is No Relationship Between HbA1C and HDL in Type 2 Diabetes Mellitus Patients

Abstract

Backgrounds: Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion. Hyperglycemia control is evaluated from the results of blood glucose control using HbA1C. Insulin resistance and hyperglycemia cause HDL function and the amount of HDL catabolized to increase, resulting in decreased HDL levels in the blood and increased HbA1C. The World Health Organization (WHO) claims that there are around 422 million individuals with diabetes worldwide, and the majority of sufferers live in low- and middle-income countries. In Indonesia, there are 19,465,100 diabetes sufferers aged between 20 and 79 years. Meanwhile, the adult population aged 20 to 79 years is 179,720,500 people, so the prevalence of diabetes in the age group of 20 to 79 years is 10.6%.

Objective: This study aims to examine the relationship between HbA1C and HDL in patients with type 2 diabetes mellitus.

Methods: This study is an observational analytical study with a cross-sectional design with consecutive non-random sampling. The subjects of this study were patients with Diabetes Mellitus aged 26 - 46 years who were treated as outpatients at the polyclinic of IZZA Hospital Cikampek. The research data were obtained from medical record data on HbA1C and HDL levels of outpatients. Data analysis was performed using SPSS 25.0 Software using the Spearman Correlation test (95% confidence level and 5% p-value).

Results: This study involved 61 subjects. High HbA1C levels were 44.26%, while normal HbA1C was 27%. Low HDL levels were 42.62%, while normal and high HDL were 57.38%. The results of the calculation of the relationship test between HbA1C and HDL in Type 2 Diabetes Mellitus Patients (p = 0.507; r = -0.086).

Conclusion: The results of the study showed that there was no significant relationship between HbA1C and HDL in Type 2 Diabetes Mellitus Patients