Meningioma or dural-based metastasis: 68Ga DOTA-TOC PET/CT as a problem-solving tool 68 Ga DOTATOC PET/CT in Meningioma

Abstract

Positron emission tomography/computed tomography (PET/CT) using ⁶⁸Ga-DOTA-conjugated peptides (⁶⁸Gallium DOTA-(Tyr3)-octreotide) is a non-invasive diagnostic technique to assess tumors with a high affinity for somatostatin receptors (SST). Besides neuroendocrine tumors, several other tumors express SST; meningioma being one of them. We report the case of a 35-year-old female, diagnosed with choriocarcinoma, and detected to have an intracranial space occupying lesion at the time of staging investigations. The patient underwent both ¹⁸F-2-fluoro-2-deoxy-D glucose (¹⁸F-FDG) and ⁶⁸Ga-DOTA-TOC PET/CT scans, which showed reduced uptake on ¹⁸F-FDG and intense uptake in the lesion on the ⁶⁸Ga-DOTA-TOC PET/CT scan. The radiological picture was suggestive of meningioma. The patient was treated with combination chemotherapy for choriocarcinoma to a state of complete serological remission, without the need to biopsy the space occupying lesion and spared the patient of escalated doses of chemotherapy. Surgical excision of the brain lesion confirmed the diagnosis of Meningioma (Grade II)