The features of the morphological and cytological changes in the lung and diaphragm in chronic purulent pneumonia. (experimental study.)

Abstract

We induce a model of experimental chronic suppurative pneumonia (e-CSP) by prolonged mechanical irritation of the bronchi by the method of Batyreva Z. B., and Shamirzaev N. X in white rats. The purpose and objectives are to study the morphology and cellular response of lung tissue and the walls of the diaphragmatic muscles in e-CSP. During the examination on 30th and 45th days from the beginning of the experiment with the background of purulent inflammation of the lungs we determined mild manifestations of inflammatory changes on the sections of the tissue. There were cellular shifts in the bronchial mucosa, lung tissue and diaphragm with lymphoid reaction and morphological changes in the tissues. These anifestations were characterized by capillary and arterial fullness, focal lymphocytic-macrophage infiltration between the alveolar septa, moderate daily edema, dystrophic and compensatory changes in the lung tissue and walls of the diaphragm. Morphological changes in rats were haracterized by focal infiltration of lymphoid elements, moderate interstitial edema with impaired blood circulation in the pulmonary tissue and the muscular part of the diaphragm wall. On drug-prints in the bronchi and, especially in the lungs, there was a "revival" of both blood and tissue protective cells at the site of inflammation. The main feature of cytological changes in the long-standing form of chronic purulent process in the lungs is a lymphoid reaction with the appearance of young plasma cells, occurring against the background of reduced activity of macrophages, indicating a decrease in the protective capabilities of the body in e-CSP. The revealed morphological and cytological changes occurring in the pulmonary and diaphragm tissues testified to simultaneous inclusion of the pulmonary tissue and diaphragm in the inflammatory process, which must be taken into account in practical health care.