Expression difference between snail and twist as New-type therapy target in patients with breast cancer: a meta-analysis

Abstract

Background: With the application of targeted drugs, the prognosis of breast cancer has significantly
ameliorated, and the survival time of patients is significantly prolonged. However, there are still
numerous of breast cancer patients with poor therapeutic effect due to no specific treatment targets.
Studies have demonstrated that block the function of epithelial-mesenchymal-transition (EMT) factors,
Snail and Twist, can significantly improve the prognosis of breast cancer. Consequently, we may take
the two factors into consideration as new therapeutic targets.
Objective: To investigate the expression difference between Snail and Twist as newly therapeutic
target in breast cancer patients.
Methods: The databases including PubMed, Embase, Web of science, CNKI and WANFANG MED
ONLINE were Retrieved. Revman software 5.0 was used to conduct fixed-effect model meta-analysis.
Results: 8 valid articles provided 2848 participants were analyzed. there was no statistical significance
in the expression difference between Snail and Twist in breast cancer (Pooled OR=1.16; 95%CI:
0.97-1.37) and the following settings: ER-positive/negative (Pooled OR=1.16; 95%CI: 0.85-1.58), PRpositive/
negative(Pooled OR=1.20; 95%CI: 0.87-1.65), HER2-overexpression/non-expression (Pooled
OR=0.94; 95%CI: 0.62-1.43), lymph nodes positive/negative (Pooled OR=1.02; 95%CI: 0.80-1.31),
patients with TNBC/non-TNBC (Pooled OR=0.93; 95%CI: 0.59-1.46), tumor stage3-4/1-2 (Pooled
OR=1.00; 95%CI: 0.74-1.36).
Conclusion: The expression difference between Snail and Twist as new-type therapy target in breast
cancer patients is not statistically significant, denoting that it is sensible to combine them together as
novel targets for the treatment of breast cancer in clinical application