Case Report of Eosinophilic Fasciitis (EF)

Abstract

A female patient in her early 30s presented with a 3-month history of progressive skin stiffness in the upper and lower limbs, accompanied by peripheral eosinophilia. Clinical examination revealed symmetric skin thickening, non-pitting edema, and joint tenderness, but no signs of systemic sclerosis or visceral involvement. Magnetic resonance imaging (MRI) demonstrated fascial thickening, and a full-thickness biopsy confirmed chronic inflammation and fibrosis of the fascia, consistent with eosinophilic fasciitis (EF). Initial treatment with highdose prednisolone resulted in partial improvement, but the development of a groove sign prompted the addition of mycophenolate mofetil and
later methotrexate. At 6-month follow-up, the patient showed marked improvement in skin tightness and resolution of edema, though joint
pain persisted. This case highlights the importance of early recognition, a multimodal diagnostic approach, and tailored treatment to prevent
long-term complications.