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Doha Mohammed alfatih basher https://orcid.org/0000-0001-7127-2378 Fadwa Mohammed Ebraheem Dalena https://orcid.org/0000-0003-4872-705X Mohammed Abdulelah Abuzied https://orcid.org/0000-0003-3659-232X Bahja Abdu Mohammed Mohajer https://orcid.org/0000-0002-8679-8214 Aisha Ali Rhoma https://orcid.org/0000-0003-3937-9874 Fatima Kamal Abdelmotalab Mohamed https://orcid.org/0000-0001-5079-8127 Fatma ZeinElabdeen Ebrahim https://orcid.org/0000-0003-0517-0079 Sawsan A. Hamed https://orcid.org/0000-0001-8170-3485 Elsadig Gasoom https://orcid.org/0000-0001-8221-1204

Abstract

Abstract:


Background:Gliomas are the most prevalent primary tumors of the brain and spinal cord which represent about 33 percent of all brain tumors. This study was designed to detect the association between TNF gene and gliomas among Sudanese patients.


Materials and Methods: This study was descriptive cross sectional study, conducted at the research laboratory of the National Center for Neurological Sciences(NCNS), Khartoum, Sudan during the period from June to September 2022. Demographical data (gender, age, residence, histology and WHO grading). DNA extraction was done from tissue of all operated patients with gliomas tumors. PCR for TNF was done and thus Sanger sequencing.


Results: The PCR results showed positive PCR for TNF gene in all samples. And sequencing result showed base bare exchange in TNF gene C to T polymorphism.


Conclusion:TNF gene polymorphism was detected and might be associated with gliomas tumors among Sudanese patients.

Abstract

Abstract:


Background:Gliomas are the most prevalent primary tumors of the brain and spinal cord which represent about 33 percent of all brain tumors. This study was designed to detect the association between TNF gene and gliomas among Sudanese patients.


Materials and Methods: This study was descriptive cross sectional study, conducted at the research laboratory of the National Center for Neurological Sciences(NCNS), Khartoum, Sudan during the period from June to September 2022. Demographical data (gender, age, residence, histology and WHO grading). DNA extraction was done from tissue of all operated patients with gliomas tumors. PCR for TNF was done and thus Sanger sequencing.


Results: The PCR results showed positive PCR for TNF gene in all samples. And sequencing result showed base bare exchange in TNF gene C to T polymorphism.


Conclusion:TNF gene polymorphism was detected and might be associated with gliomas tumors among Sudanese patients.

Keyword : Keywords:Gliomas, TNF gene, PCR, sequencing, and polymorphism.

How to Cite
basher, D. M. alfatih, Dalena, F. M. E. ., Abuzied, M. A., Mohajer, B. A. M., Rhoma, A. A., Abdelmotalab Mohamed, F. K. ., Ebrahim, F. Z., Hamed, S. A. ., & Gasoom, E. (2023). The Role of TNF Gene RS18715293, SNV101403225 and SNV69305309 in Gliomas Tumors Among Sudanese Patients. Journal of Medical Case Reports and Reviews, 6(02). Retrieved from http://jmcrr.info/index.php/jmcrr/article/view/251
  Submitted
Jan 26, 2023
Published
Feb 6, 2023
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