The Role of TNF Gene RS18715293, SNV101403225 and SNV69305309 in Gliomas Tumors Among Sudanese Patients.

Doha Mohammed alfatih basher (1) , Fadwa Mohammed Ebraheem Dalena (2) , Mohammed Abdulelah Abuzied (3) , Bahja Abdu Mohammed Mohajer (4) , Aisha Ali Rhoma (5) , Fatima Kamal Abdelmotalab Mohamed (6) , Fatma ZeinElabdeen Ebrahim (7) , Sawsan A. Hamed (8) , Elsadig Gasoom (9)
(1) Faculty of Medical Laboratory Sciences, Al-Neelain University, Sudan. , Sudan
(2) Faculty of Medical Laboratory Sciences, El-Daein University, Sudan. , Sudan
(3) Faculty of Medical Laboratory Sciences, Al-Neelain University, Sudan. , Sudan
(4) Faculty of Medical Laboratory Sciences, Al-Neelain University, Sudan. , Sudan
(5) Faculty of Medical Laboratory Sciences, Al-Neelain University, Sudan. , Sudan
(6) Faculty of Medical Laboratory Sciences, Al-Neelain University, Sudan. , Sudan
(7) Faculty of Medical Laboratory Sciences, Al-Neelain University, Sudan. , Sudan
(8) National Center for Neurological Sciences, Khartoum, Sudan , Sudan
(9) National Center for Neurological Sciences, Khartoum, Sudan , Sudan

Article Sidebar

Issue
Vol. 6 No. 02 (2023)
Keywords:
    Keywords:Gliomas, TNF gene, PCR, sequencing, and polymorphism.
PDF

Abstract

Abstract:


Background:Gliomas are the most prevalent primary tumors of the brain and spinal cord which represent about 33 percent of all brain tumors. This study was designed to detect the association between TNF gene and gliomas among Sudanese patients.


Materials and Methods: This study was descriptive cross sectional study, conducted at the research laboratory of the National Center for Neurological Sciences(NCNS), Khartoum, Sudan during the period from June to September 2022. Demographical data (gender, age, residence, histology and WHO grading). DNA extraction was done from tissue of all operated patients with gliomas tumors. PCR for TNF was done and thus Sanger sequencing.


Results: The PCR results showed positive PCR for TNF gene in all samples. And sequencing result showed base bare exchange in TNF gene C to T polymorphism.


Conclusion:TNF gene polymorphism was detected and might be associated with gliomas tumors among Sudanese patients.

Full text article

Generated from XML file

Authors

Doha Mohammed alfatih basher
Faculty of Medical Laboratory Sciences, Al-Neelain University, Sudan.
https://orcid.org/0000-0001-7127-2378
dohabasher95@gmail.com (Primary Contact)
Fadwa Mohammed Ebraheem Dalena
Faculty of Medical Laboratory Sciences, El-Daein University, Sudan.
https://orcid.org/0000-0003-4872-705X
Mohammed Abdulelah Abuzied
Faculty of Medical Laboratory Sciences, Al-Neelain University, Sudan.
https://orcid.org/0000-0003-3659-232X
Bahja Abdu Mohammed Mohajer
Faculty of Medical Laboratory Sciences, Al-Neelain University, Sudan.
https://orcid.org/0000-0002-8679-8214
Aisha Ali Rhoma
Faculty of Medical Laboratory Sciences, Al-Neelain University, Sudan.
https://orcid.org/0000-0003-3937-9874
Fatima Kamal Abdelmotalab Mohamed
Faculty of Medical Laboratory Sciences, Al-Neelain University, Sudan.
https://orcid.org/0000-0001-5079-8127
Fatma ZeinElabdeen Ebrahim
Faculty of Medical Laboratory Sciences, Al-Neelain University, Sudan.
https://orcid.org/0000-0003-0517-0079
Sawsan A. Hamed
National Center for Neurological Sciences, Khartoum, Sudan
https://orcid.org/0000-0001-8170-3485
Elsadig Gasoom
National Center for Neurological Sciences, Khartoum, Sudan
https://orcid.org/0000-0001-8221-1204
basher, D. M. alfatih, Dalena, F. M. E. ., Abuzied, M. A., Mohajer, B. A. M., Rhoma, A. A., Abdelmotalab Mohamed, F. K. ., Ebrahim, F. Z., Hamed, S. A. ., & Gasoom, E. (2023). The Role of TNF Gene RS18715293, SNV101403225 and SNV69305309 in Gliomas Tumors Among Sudanese Patients. Journal of Medical Case Reports and Reviews, 6(02). Retrieved from http://jmcrr.info/index.php/jmcrr/article/view/251
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX
Copyright and license info is not available

Article Details

Most read articles by the same author(s)