Evaluation of in vitro and anti – cancer activity of methanolic and aqueous extracts of abutilon indicum linn.

Abstract

Abutilon indicum belonging to family Malvaceae is distributed throughout number of tropical and subtropical areas and subtropical zones and has been used for various disorders in traditional and folk medicine. Medicinal herbs play an important role in primary health care system among rural population since synthetic anti-cancer remedies are beyond the reach of common man because of the cost factor. The herbal medicines have a vital role in the prevention and treatment of cancer which execute their therapeutic effect by inhibiting cancer activating enzymes and hormones, stimulating DNA repair mechanism.

Methodology: Extract were tested for the presence of active principle agents such as Triterpenoids,Steroids,Glycosides,Saponins, Alkaloid, Flavonoids, Tannins, Proteins, Free Amino Acid, Carbohydrate and lignin.

Results: The result of the study shows Methanolic and Aqueous Extract possessed an Anti-neoplastic property comparing these two extracts Methanolic extract is more potent than Aqueous extract.) Were evaluated against six different cell lines (Lung A549, NCI-H23, Colon -205, SW- 620, Liver- HEP- 2, Ovary –OVCAR—5, Breast-mcf- 7, Prostate – DU – 145). Comparing Methanolic and Aqueous Methanolic extract exhibited 95% of the Anti-neoplastic potential against the Human Cancer cell origins.