Small cell carcinoma with paraneoplastic Cushing's syndrome in a 23 -Year-Old. A New Observation And Literature Review

Abstract

A 23 years old girl, without history, consulted for a neck tumefaction appeared 20 days ago, which spread then to the abdomen and lower limbs with Asthenia, dysphagia, abdominal pain, effort dyspnea. Clinical examination revealed an altered general state, obesity with centripetal fat deposition face, supraclavicular and dorsal and cervical fat pads, facial plethora, rounded face, buffalo-hump, face acne, melanodermia, capillary fragility, face, arms and legs hirsutism.

Imaging revealed a voluminous left para-mediastinal Mass. A guided Scan biopsy confirmed the diagnosis of small cell neuroendocrine carcinoma.

The patient had a first line treatment with Etoposide-Carboplatin. Initially the response to the treatment was good with improvement of symptoms. At day 20 of the treatment, the patient had a clinical progression and died after 15 days.