Phenytoin Induced Exanthematous Rash with Severe Leukopenia and Anemia-A Case Report

Abstract

Phenytoin  isthe most common  andwidely    used  antiepileptic    drug.It    is  used    for  the prevention    and  treatment    of    generalized    seizures,    partial  seizures    and  status    epileptics. Cutaneous  reactions  are  a  common  adverse  effect  associated  with  antiepileptic  drugs  (AEDs)  and  a cause of treatment discontinuation. Such reactions range from mild rashes to more serious conditions such  as  Stevens-Johnson  syndrome  and  toxic  epidermal  necrolysis [1].  With  phenytoin  ,  for  instance, skin rashes occur in up to 16% of patients at the beginning of therapy